Jamshedpur: A recent study has thrown light on a vast extent of association between the extra Y chromosome and increased risk of being diagnosed with autism. Here, it has also thrown new light on gender discrepancies observed in the incidence rates of autism. Researchers at Autism and Developmental Medicine Institute, in the U.S conducted a cross-sectional study with more than 177,000 patients, looking specifically for genetic data on the abnormalities of patients, especially in XYY and XXY sex chromosomes.
Findings indicate that surplus Y chromosomes meant individuals were twice as likely to receive an autism diagnosis in comparison with those with a standard chromosomal pattern. Especially, the study concluded that XYY is at more risk for autism than is the case with XXY. This study considers it necessary to understand the risk factor of autism related to the Y chromosome, challenging the current notion wherein the X chromosome has been considered to have a protective action especially towards females.
Traditionally, the diagnosis has occurred almost four times as frequently in males than females. These theories have created notions of тАШfemale protective effectтАЩ as the scientists consider the existence of two X chromosomes can protect women against this problem. In fact, new research study in Nature Communications argues to put more effort on looking at the possibility of factors which may affect a male with autism within the Y chromosome.
Based on their findings, the researchers insist on further research into the specific genetic factors associated with the Y chromosome that can contribute to autism. In fact, they argue a deeper understanding of these mechanisms will lead to more effective interventions and support services.
